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Abstract #4011

DW-MRI evaluation of the serial changes of diffusion and microperfusion in adriamycin induced renal injury rat

Haoran Sun 1 , Huanhuan Wu 2 , and Ziheng Zhang 3

1 Radiology, Tianjin Medical University Hospital, Tianjin, Tianjin, China, 2 Tianjin Medical University Hospital, China, 3 MR Research China,GE Healthcare, Shanghai, China

Intravoxel incoherent motion (IVIM) DWI has recently shown potential to assess functional changes of chronic kidney diseases. This study is to evaluate the feasibility of the mono- and bi-exponential models measurements through multi-b DW-MRI in reflection of the serial variation of diffusion and microperfusion noninvasively on adriamycin induced rodent renal injury models. It was found the serial variation of ADC, f, D* values are sensitive to the progression of renal disorder induced by adriamycin and according to the histological findings, which suggests one, we can noninvasively assess renal injury according using DW-MRI method.

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