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Abstract #4012

Quantification of Intrapancreatic Fat (IPF) using 1H-MR Spectroscopy and Multi-Echo Dixon: A Feasibility Study

Annelise M Silva 1,2 , Anshuman Panda 3 , Raul Pannala 4 , Vijay P Singh 4 , Krutika Patel 4 , Vishnu T Kommineni 4 , Teresa Wu 5 , Yinlin Fu 5 , and Alvin C Silva 3

1 Research, Mayo Clinic, Phoenix, Arizona, United States, 2 Arizona State University, Tempe, Arizona, United States, 3 Radiology, Mayo Clinic, Phoenix, Arizona, United States, 4 Gastroenterology, Mayo Clinic, Phoenix, Arizona, United States, 5 School of Computing, Informatics, and Decision Systems Engineering, Arizona State University, Tempe, Arizona, United States

There is increasing evidence that excess intrapancreatic fat (IPF) has deleterious effects and plays a role in various disease states including diabetes, pancreatitis, and the metabolic syndrome. Moreover, it may also predispose to pancreatic cancer in association with increased dietary fat intake. At present, IPF assessment is subjective, without a standardized tool for accurate noninvasive evaluation. Our goal is to develop and validate a comprehensive MR imaging protocol for noninvasive fat quantification of the entire pancreas. Specifically, MR Spectroscopy and Multi-Echo Dixon techniques will be optimized and validated for their efficacy in providing accurate intra-pancreatic fat (IPF) quantification.

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