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Abstract #4013

Examining intrauterine growth restriction due to placental insufficiency in fetal guinea pigs in utero using MRI

Kevin J Sinclair 1 , Lanette J Friesen-Waldner 1 , Colin M McCurdy 1 , Curtis N Wiens 2 , Trevor P Wade 1,3 , Barbra de Vrijer 4 , Timothy RH Regnault 4,5 , and Charles A McKenzie 1,3

1 Medical Biophysics, University of Western Ontario, London, Ontario, Canada, 2 Radiology, University of Wisconsin, Madison, Wisconsin, United States, 3 Robarts Research Institute, University of Western Ontario, London, Ontario, Canada, 4 Obstetrics and Gynaecology, University of Western Ontario, London, Ontario, Canada, 5 Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada

Growth restricted fetuses have been identified as being at increased risk of later life metabolic and cardiovascular disease. The purpose of this study was to identify developmental abnormalities in growth restricted guinea pig fetuses compared to healthy normals using MRI. Two maternal groups were scanned: one in which branches of the uterine artery were ablated to promote growth restriction of the fetuses, and a sham surgical group. Segmentation of anatomical and water-fat images of pregnant guinea pigs (N = 10) demonstrated asymmetrical growth restriction as well as a decrease in adipose tissue in growth restricted fetuses compared to normal.

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