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Abstract #4014

Assessing renal ischemia/reperfusion injury in mice using time-dependent BOLD and DTI at 9.4T

Dong-Cheol Woo 1 , Do-Wan Lee 1 , Nayoung Kim 1 , Chul-Woong Woo 1 , Sang-Tae Kim 1 , Jeong-Kon Kim 1 , Kyungwon Kim 1 , Youyol Song 1 , Hyun-Kwon Ha 1 , and Jin Seong Lee 1

1 Asan Institute for Life Sciences, Asan Medical Center, Seoul, Seoul, Korea

The first goal of this study was to quantitatively assess regional changes in function and pathophysiological characteristics in renal IR injured mice and compare data obtained at baseline and following injury. The second goal was to correlate BOLD and DTI data using time-dependent scans. Our current findings suggest that MRI could be used to obtain pathophysiological data from separate renal compartments in IR-injured mice. Hence, BOLD and DTI may also provide functional and pathophysiological data on the allograft status following kidney transplant without the need to use a contrast agent.

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