Abstract #4026
Early Changes in Renal Hypoxia Following Iodinated Contrast: Need for Real-time Monitoring
Lu-Ping Li 1,2 , Jing Lu 2,3 , Tammy Franklin 1 , Ying Zhou 4 , Richard Solomon 5 , and Pottumarthi V. Prasad 1,2
1
Department of Radiology / Center for
Advanced Imaging, Northshore University Healthsystem,
Evanston, IL, United States,
2
Pritzker
School of Medicine, University of Chicago, Chicago, IL,
United States,
3
Department
of Obstetrics and Gynecology, Northshore University
Healthsystem, Evanston, IL, United States,
4
Center
for Clinical & Research Informatics, Northshore
University Healthsystem, Evanston, IL, United States,
5
Nephrology,
University of Vermont, VT, United States
The current clinical marker (serum creatinine) is not
time-sensitive to guide intervention to prevent
iodinated contrast induced acute kidney injury (CIAKI).
Blood-oxygenation-level dependent (BOLD) MRI showed near
real time changes in renal hypoxia following contrast
administration in a previous functional CIAKI rat model.
In this study, streptozotocin induced diabetic rat was
used as a CIAKI susceptible model. While the renal
hypoxia in medulla increased following contrast
administration, it fell back towards baseline. Urinary
NGAL increasing confirmed AKI. This indicates the need
for real time marker to monitor the temporal changes of
renal hypoxia during contrast administration.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
