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Abstract #4028

Preclinical Magnetic Resonance Fingerprinting: Taking Advantage of Inherent Resistance to Motion Artifacts

Ying Gao 1 , Yong Chen 2 , Dan Ma 1 , Yun Jiang 1 , Katherine M. Dell 3 , Mitchell L. Drumm 3,4 , Mark A. Griswold 1,2 , Chris A. Flask 1,2 , and Lan Lu 2,5

1 Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States, 2 Radiology, Case Western Reserve University, Cleveland, Ohio, United States, 3 Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States, 4 Genetics, Case Western Reserve University, Cleveland, Ohio, United States, 5 Urology, Case Western Reserve University, Cleveland, Ohio, United States

Conventional MRI methods are highly susceptible to motion artifacts, especially for preclinical body imaging applications. We have implemented an MRF-FISP acquisition on a high field preclinical MRI scanner to simultaneously obtain in vivo T 1 , T 2 , and proton density maps for both healthy and polycystic kidneys in mice and rats. Initial results show that our preclinical MRF technique can provide reasonable estimates of relaxation times and proton density and is sensitive to known pathology. Most importantly, these results confirm that the MRF technique is inherently resistant to respiratory motion artifacts which is a key advantage for body imaging applications.

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