Abstract #4041
MR-ARFI for the Quantification of Tissue Elastic Properties
Tetiana Dadakova 1 , Ali Caglar zen 1 , Axel Joachim Krafft 1 , Jurgen Ftterer 2 , Martijn Hoogenboom 2 , Jrgen Walter Jenne 3 , Erik Dumont 4 , Christakis Damianou 5 , Jan Gerrit Korvink 6 , and Michael Bock 1
1
Department of Radiology - Medical Physics,
University Medical Center Freiburg, Freiburg, Germany,
2
Department
of Radiology and Nuclear medicine, Radboud University
Medical Center, Nijmegen, Netherlands,
3
Fraunhofer
MEVIS, Bremen, Germany,
4
Image
Guided Therapy, Pessac, France,
5
Department
of Electrical Engineering, Computer Engineering and
Informatics, Cyprus University of Technology, Limassol,
Cyprus,
6
Department
of Microsystems Engineering (IMTEK), University of
Freiburg, Freiburg, Germany
High intensity focused ultrasound (HIFU) under MR
guidance allows for pre-treatment planning,
post-treatment assessment and real-time temperature
monitoring during treatment in ablative hyperthermia of
tumors. In addition to heating, HIFU causes micrometer
transient displacements in the tissue, which is most
pronounced at the focal spot. The displacement can be
visualized with MRI (acoustic radiation force imaging,
ARFI) using motion encoding gradients. The
time-dependency of the displacement can be described by
an overdamped harmonic oscillator model, which has two
parameters: the maximum tissue displacement ∆x, and the
rise time τ. The rise time is related to the mechanical
tissue properties, and its quantification is needed for
modelling of the tissue response during ARFI, and to
distinguish tissues based on their stiffness. In this
work we developed a method to quantify τ from MR-ARFI
data. To assess whether tissue stiffness changes with
heating, τ was calculated in 4 regions of a porcine
muscle ex vivo phantom, which received different thermal
doses.
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