Pre-Clinical Head-Mounted MRgFUS Device for Large Animals

This work describes an MRgFUS system for conducting ultrasound procedures on large animals on a Siemens 3T MRI scanner. A craniotomy was performed on a pig to provide unobstructed passage of ultrasound during treatment. A seven-channel phased array RF coil was used for ultrasound guidance and MR thermometry. A multi-axis adjustment mechanism suspended the ultrasound transducer above the prone animal, and allowed for a treatment envelope covering the majority of the brain volume. Two brain locations were targeted and heating was successfully observed, verifying the ultrasound focus position. The system can be easily adapted to other animals and anatomy.

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