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Abstract #4047

Investigating the utility of diffusion-weighted imaging (DWI) for monitoring treatment efficacy during MR guided High Intensity Focused Ultrasound (MRgHIFU) therapy in bone applications

Sharon L Giles 1 , Jessica M Winfield 2 , Ian Rivens 3 , David J Collins 2 , Gail R ter Haar 3 , and Nandita M deSouza 2

1 MRI Unit, Royal Marsden Hospital, Sutton, Surrey, United Kingdom, 2 CRUK Cancer Imaging Centre, The Institute of Cancer Research, Sutton, Surrey, United Kingdom, 3 Therapeutic Ultrasound, The Institute of Cancer Research, Sutton, Surrey, United Kingdom

This study assesses the utility of DWI for detecting tissue changes during MRgHIFU by evaluating repeatability of ADC measurements and ADC changes after sonication in n=7 lamb legs. Measurements were made in soft tissues immediately adjacent to bone. Imaging appearances were macroscopically compared with dissected tissues. The coefficient of variation for repeat ADC measurements was 1.0% and the degree of ADC change increased with increasing power of sonications. A 20% sustained increase in ADC produced visible lesions on dissection, unapparent on T1- or T2-W imaging, making DWI a potential tool for monitoring damage during MRgHIFU in bone applications.

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