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Abstract #4052

Localized hyperthermia in rodent models using a MRI-compatible high-intensity focused ultrasound system

Chenchen Bing 1 , Joris Nofiele 1 , Robert Staruch 1,2 , Yonatan Chatzinoff 1 , Michele Harbeson 3 , Danny Maples 3 , Jerry Malayer 3 , Samuel Pichardo 4 , Ashish Ranjan 3 , and Rajiv Chopra 1

1 Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2 Clinical Sites Research Program, Philips Research North Amarica, Briarcliff Manor, NY, United States, 3 Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, United States, 4 Thunder Bay Regional Research Institute, Thunder Bay, ON, Canada

Temperature-sensitive drug carriers are able to induce a fast release of active drugs in the target region, which will solve the problem of causing systemic toxicity during traditional chemotherapy. An MRI-compatible high-intensity focused ultrasound (MR-HIFU) system was developed to perform localized hyperthermia in rodent models. This MR-HIFU system can conduct precise-controlled thermal therapies to allow heat-mediated drug delivery in small animal models. Feasibility and performance of the system is well evaluated with phantom and in-vivo experiment.

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