Localized hyperthermia in rodent models using a MRI-compatible high-intensity focused ultrasound system
Chenchen Bing 1 , Joris Nofiele 1 , Robert Staruch 1,2 , Yonatan Chatzinoff 1 , Michele Harbeson 3 , Danny Maples 3 , Jerry Malayer 3 , Samuel Pichardo 4 , Ashish Ranjan 3 , and Rajiv Chopra 1
Radiology, UT Southwestern Medical Center,
Dallas, TX, United States,
Sites Research Program, Philips Research North Amarica,
Briarcliff Manor, NY, United States,
for Veterinary Health Sciences, Oklahoma State
University, Stillwater, OK, United States,
Bay Regional Research Institute, Thunder Bay, ON, Canada
Temperature-sensitive drug carriers are able to induce a
fast release of active drugs in the target region, which
will solve the problem of causing systemic toxicity
during traditional chemotherapy. An MRI-compatible
high-intensity focused ultrasound (MR-HIFU) system was
developed to perform localized hyperthermia in rodent
models. This MR-HIFU system can conduct
precise-controlled thermal therapies to allow
heat-mediated drug delivery in small animal models.
Feasibility and performance of the system is well
evaluated with phantom and in-vivo experiment.
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