Abstract #4052
Localized hyperthermia in rodent models using a MRI-compatible high-intensity focused ultrasound system
Chenchen Bing 1 , Joris Nofiele 1 , Robert Staruch 1,2 , Yonatan Chatzinoff 1 , Michele Harbeson 3 , Danny Maples 3 , Jerry Malayer 3 , Samuel Pichardo 4 , Ashish Ranjan 3 , and Rajiv Chopra 1
1
Radiology, UT Southwestern Medical Center,
Dallas, TX, United States,
2
Clinical
Sites Research Program, Philips Research North Amarica,
Briarcliff Manor, NY, United States,
3
Center
for Veterinary Health Sciences, Oklahoma State
University, Stillwater, OK, United States,
4
Thunder
Bay Regional Research Institute, Thunder Bay, ON, Canada
Temperature-sensitive drug carriers are able to induce a
fast release of active drugs in the target region, which
will solve the problem of causing systemic toxicity
during traditional chemotherapy. An MRI-compatible
high-intensity focused ultrasound (MR-HIFU) system was
developed to perform localized hyperthermia in rodent
models. This MR-HIFU system can conduct
precise-controlled thermal therapies to allow
heat-mediated drug delivery in small animal models.
Feasibility and performance of the system is well
evaluated with phantom and in-vivo experiment.
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