MR-GUIDED HIGH INTENSITY FOCUSED ULTRASOUND FOR ABLATED KIDNEY: MR PERFUSION ASSESSMENT AND MICROSCOPIC CHARACTERIZATION

This swine study aimed to demonstrate the perfusion deficits, as an early indicator, of successful thermal MRg-HIFU ablation. Kidneys (n=12) were ablated after minimizing diaphragm motion using rocuronium injection and breath-hold. Saturation recovery-GRE was used after ablation to monitor regional perfusion in ablated, viable and aortic blood to obtain perfusion data. This study shows the potential of perfusion imaging as an early indicator of successful ablation. Thermal MRg-HIFU causes loss of vascular and cellular integrity. The severity of injury is dependent on the energy used. Thus, the used energy must be optimized in the kidney for future translation to clinic.

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