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Abstract #4050

MRI Guided High Intensity Focused Ultrasound (HIFU) of Visceral Fat in Overweight Rats

Patrick Winter 1 , Matthew Lanier 1 , Ari Partanen 2 , and Charles Dumoulin 1

1 Radiology, Cincinnati Childrens Hospital, Cincinnati, OH, United States, 2 Clinical Science MR Therapy, Philips Healthcare, Andover, MA, United States

MRI-guided HIFU (MR-HIFU) allows non-invasive ablation of deep tissues. MR-HIFU could be used to treat obesity and diabetes by heating body fat. Conventional MR thermometry methods cannot monitor temperature changes in fat. Instead, we used T2 mapping to evaluate the effects of HIFU on fat at 1.5T. Whole body heating experiments showed that fat T2 increased by 3.3 ms for every C of heating. Immediately after HIFU, the T2 at the target increased by 17.7 ms, corresponding to 42.4 C. A clear therapeutic effect was observed ten days after MR-HIFU, with rats losing 7.5 1.2 % body weight.

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