Abstract #4050
MRI Guided High Intensity Focused Ultrasound (HIFU) of Visceral Fat in Overweight Rats
Patrick Winter 1 , Matthew Lanier 1 , Ari Partanen 2 , and Charles Dumoulin 1
1
Radiology, Cincinnati Childrens Hospital,
Cincinnati, OH, United States,
2
Clinical
Science MR Therapy, Philips Healthcare, Andover, MA,
United States
MRI-guided HIFU (MR-HIFU) allows non-invasive ablation
of deep tissues. MR-HIFU could be used to treat obesity
and diabetes by heating body fat. Conventional MR
thermometry methods cannot monitor temperature changes
in fat. Instead, we used T2 mapping to evaluate the
effects of HIFU on fat at 1.5T. Whole body heating
experiments showed that fat T2 increased by 3.3 ms for
every C of heating. Immediately after HIFU, the T2 at
the target increased by 17.7 ms, corresponding to 42.4
C. A clear therapeutic effect was observed ten days
after MR-HIFU, with rats losing 7.5 1.2 % body weight.
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