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Abstract #4062

Multivoxel Proton Magnetic Resonance Spectroscopy for Non-Invasive Thermometry: Improvements in Spectral Quality using semiLASER with GRE Shim

Candace C. Fleischer 1,2 , Deqiang Qiu 3 , Xiaodong Zhong 4 , Hui Mao 3 , John N. Oshinksi 3 , Xiaoping Hu 1,2 , and Seena Dehkharghani 3

1 Biomedical Imaging Technology Center, Emory University, Atlanta, GA, United States, 2 Biomedical Engineering, Emory University, Atlanta, GA, United States, 3 Radiology and Imaging Sciences, Emory University Hospital, Atlanta, GA, United States, 4 MR R&D Collaborations, Siemens Healthcare, Atlanta, GA, United States

Current brain thermometry methods are costly and highly invasive. Chemical shift imaging (CSI) is a promising technique for non-invasive thermometry utilizing temperature-dependent chemical shift differences between water and N-acetylaspartate. The current standard using a PRESS sequence with automated shimming suffers from poor spatial resolution and chemical shift artifacts. We present a CSI protocol for thermometry with quantitative improvements to shimming and spectral quality in vitro and in vivo: a semiLASER spectroscopy sequence with GRE Shim. Combining the semiLASER advanced voxel localization with a more homogenous magnetic field from GRE Shim will be beneficial for thermometry and other applications of CSI.

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