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Abstract #4072

Proton density fat fraction and liver water and fat T2 as measured by multi-TR, multi-TE 1 H MRS compared to multi-TE 1 H MRS.

Gavin Hamilton 1 , Michael S Middleton 1 , Alexandra N Schlein 1 , Catherine A Hooker 1 , Lisa Clark 1 , Rohit Loomba 2 , and Claude B Sirlin 1

1 Department of Radiology, UC San Diego, San Diego, California, United States, 2 Department of Medicine, UC San Diego, San Diego, California, United States

We developed a rapid multi-TR, multi-TE 1 H MRS sequence for in vivo hepatic fat quantification and characterization that acquires 32 single-average spectra in a single breath-hold. Here we compare the estimates of water and fat T2 and proton density fat fraction (PDFF) given by the multi-TR, multi-TE sequence with those given by the current MRS standard: a long-TR, multi-TE sequence. We find good agreement between the sequence estimates of PDFF and water T2. However there is little agreement for fat T2.

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