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Abstract #4075

MRI-R2* Relaxometry for cardiac, pancreatic and hepatic iron assessment in patients with Hereditary Hemochromatosis

Sarah Keller 1 , Bjoern Schoennagel 1 , Zhiyue Jerry Wang 2 , Regine Grosse 3 , Peter Nielsen 4 , Gerhard Adam 1 , Roland Fischer 1 , and Jin Yamamura 1

1 Diagnostic and Interventional Radiology, University Medicine Hamburg Eppendorf, Hamburg, Germany, 2 Radiology, Children's Medical Center Dallas, Dallas, Texas, United States, 3 Pediatric Hematology and Oncology, University Medicine Hamburg Eppendorf, Hamburg, Germany, 4 Institute of Biochemistry and Molecular Biology, Center of Experimental Medicine, Hamburg, Germany

Hereditary hemochromatosis (HH) is frequently associated with cardiomyopathy and iron accumulation in the heart beyond increased hepatic iron concentration (HIC). Measurements of cardiac and hepatic iron concentration in patients with HH are rare (Olson et al, 1987) and sporadic cases seem to be reported less frequently. MRI-R2* Relaxometry combined with Biosusceptometry was performed to assess cardiac, hepatic and pancreatic iron accumulation and relative fat/water content in 7 homozygotes with HH (C282Y: n=4, H63D: n=3).

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