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Abstract #4079

Liver Iron Content Determination using GRE and Signal Intensity Ratio Analysis in MR Systems from Different Vendors

Arthur Peter Wunderlich 1,2 , Meinrad Beer 1 , Peter Bernhardt 3 , Holger Cario 4 , Vinzenz Hombach 3 , Reinhard Meier 1 , Wolfgang Rottbauer 3 , Stefan Andreas Schmidt 1 , and Volker Rasche 3

1 Clinic for Diagnostic and Interventional Radiology, Univ.-Clinic Ulm, Ulm, Germany, 2 Section for Experimental Radiology, Univ.-Clinic Ulm, Ulm, Germany, 3 Clinic for Internal Medicine II - Cardiology, Univ.-Clinic Ulm, Ulm, Germany, 4 Clinic for Pediatrics, Univ.-Clinic Ulm, Ulm, Germany

Since existing methods for determining Liver Iron Content (LIC) are based on Signal Intensity Ratio (SIR), we studied compatibility of SIR values between scanners from different vendors. Patients suspected for liver iron overload were examined at two different scanners the same day at 1.5 T. SIR values of in-phase GRE images calculated from three liver ROIs and two in paraspinal muscles, and LIC calculated using SIR obtained from both scanners were compared by statistical methods. SIR values showed good correlation but didnt match properly. However, calculated LIC values were in good agreement between scanners, especially when working with RF spoiling.

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