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Abstract #4080

Pancreatic Iron: A Future Major Organ in Iron Overload Diseases - The Role of R2*-Relaxometry

Jin Yamamura 1 , Sarah Keller 1 , Bjrn Schnnagel 1 , Regine Grosse 2 , Zhiyue Jerry Wang 3 , Peter Nielsen 4 , Gerhard Adam 1 , and Roland Fischer 1,5

1 Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany, 2 Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany, 3 Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States, 4 Biochemistry, University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany, 5 Department of Radiology, Children's Hospital & Research Center Oakland, Oakland, California, United States

This study aims to determine the pancreatic iron and fat content in patients with iron overload.Highest iron and fat content was found in the pancreatic tail and pancreatic R2* correlated with cardiac iron deposition. Besides iron accumulation, fatty degeneration might be an additional risk factor for the development of diabetes and might also explain the early onset of diabetes in these patients.

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