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Abstract #4082

Quantification of hepatic and myocellular glycogen after two days of diet and activity standardization: a 13 C MRS reproducibility study in individuals with type 1 diabetes and matched healthy controls

Tania Buehler 1 , Lia Bally 2 , Ayse Sila Dokumaci 1 , Christoph Stettler 2 , and Chris Boesch 1

1 Depts. Radiology and Clinical Research, University Bern, Bern, Switzerland, 2 Division of Endocrinology, Diabetes and Clinical Nutrition, Inselspital Bern, Bern, Switzerland

Glycogen metabolism plays a major role in glucose homeostasis in healthy (HEAL) and type 1 diabetes mellitus (T1DM) subjects. Despite the widespread use in metabolic research of MRS to measure glycogen, there is currently scarce data on its variability in T1DM subjects. Based on non-invasive natural abundance 13C MRS the present study investigated longitudinal reproducibility of hepatic and myocellular glycogen stores in healthy (CV 12%, 16% respectively) and T1DM (CV 16%, 9% respectively) subjects following prior a diet- and activity-standardization protocol. The findings can have important implications on e.g. the design of interventional trials assessing exercise-related fuel metabolism in T1DM.

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