Abstract #4082
Quantification of hepatic and myocellular glycogen after two days of diet and activity standardization: a 13 C MRS reproducibility study in individuals with type 1 diabetes and matched healthy controls
Tania Buehler 1 , Lia Bally 2 , Ayse Sila Dokumaci 1 , Christoph Stettler 2 , and Chris Boesch 1
1
Depts. Radiology and Clinical Research,
University Bern, Bern, Switzerland,
2
Division
of Endocrinology, Diabetes and Clinical Nutrition,
Inselspital Bern, Bern, Switzerland
Glycogen metabolism plays a major role in glucose
homeostasis in healthy (HEAL) and type 1 diabetes
mellitus (T1DM) subjects. Despite the widespread use in
metabolic research of MRS to measure glycogen, there is
currently scarce data on its variability in T1DM
subjects. Based on non-invasive natural abundance 13C
MRS the present study investigated longitudinal
reproducibility of hepatic and myocellular glycogen
stores in healthy (CV 12%, 16% respectively) and T1DM
(CV 16%, 9% respectively) subjects following prior a
diet- and activity-standardization protocol. The
findings can have important implications on e.g. the
design of interventional trials assessing
exercise-related fuel metabolism in T1DM.
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