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Abstract #4084

Measuring the unsaturation index in red and yellow bone marrow using 1 H MR spectroscopy

Alessandra Bierwagen 1,2 , Bettina Nowotny 1,2 , Julia Szendroedi 1,3 , Karsten Mssig 1,3 , Michael Roden 1,3 , and Jesper Lundbom 1,2

1 Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research, Heinrich Heine University, Duesseldorf, Germany, 2 German Center for Diabetes Research (DZD e.V.), Partner Dsseldorf, Duesseldorf, Germany, 3 Department of Endocrinology and Diabetology, University Hospital Duesseldorf, Germany

This study compared intrasubject changes in lipid unsaturation in yellow and red bone marrow and correlated these parameters to physical activity, age and BMI. Long-TE 1 H MRS spectra were acquired in the bone marrow of the femur of 9 female subjects. The mean unsaturation index of the red bone marrow was significantly lower than the unsaturation index of yellow bone marrow. RBM unsaturation correlated with the BAECKE sport index. Furthermore the fat content of the red bone marrow correlated with age.

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