Abstract #4092
Primary Study of MR Diffusion Tensor Imaging in hepatocellular carcinomas
xinghui li 1 , xiaoming zhang 2 , and jiani hu 3
1
Department of Radiology, Affiliated Hospital
of North Sichuan Medical College, nanchong, sichuan,
China,
2
Department
of Radiology, Affiliated Hospital of North Sichuan
Medical College, sichuan, China,
3
Department
of Radiology, Wayne State University, MI, United States
DTI can noninvasively provide functional information
that indirect assessment of cellularity and the
heterogeneity of the biology of HCC. An evaluation of
the clinical effectiveness of using DTI to study HCC has
thus far not been reported, moreover, no reports on the
optimized parameters of liver DTI have been published.
Therefore, the purpose of this study is to determine a
set of optimized parameter and the feasibility of
evaluating HCC using DTI. Major results of this study
were: 1) There was no significant change in liver IQ
with increased NED (P>0.05), whereas the liver IQ
decreased significantly with increased B values
(P<0.05); 2) NED=9 and B value = 500s/mm2 were chosen as
the optimal set of parameters for liver; 3) Using the
new optimized DTI sequence, ADC value of HCC lesions
were significantly lower than those of normal right
liver (1.30+ 0.34 vs 1.52+ 0.2710−3mm2/s, P=0.013) and
the mean FA value of HCC lesions was significantly
higher than normal right liver (0.42+ 0.11vs 0.32 +
0.10, P=0.004). Results demonstrate that the diffusion
in HCC lesions should be restricted and anisotropic,
which points out low ADC value and high FA value provide
useful information about celluar changes induced by HCC,
therefore, DTI can detect cellular changes induced by
HCC in a typical clinical setting, HCC lead to higher FA
values and lower ADCs on DTI than healthy liver.
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