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Abstract #4092

Primary Study of MR Diffusion Tensor Imaging in hepatocellular carcinomas

xinghui li 1 , xiaoming zhang 2 , and jiani hu 3

1 Department of Radiology, Affiliated Hospital of North Sichuan Medical College, nanchong, sichuan, China, 2 Department of Radiology, Affiliated Hospital of North Sichuan Medical College, sichuan, China, 3 Department of Radiology, Wayne State University, MI, United States

DTI can noninvasively provide functional information that indirect assessment of cellularity and the heterogeneity of the biology of HCC. An evaluation of the clinical effectiveness of using DTI to study HCC has thus far not been reported, moreover, no reports on the optimized parameters of liver DTI have been published. Therefore, the purpose of this study is to determine a set of optimized parameter and the feasibility of evaluating HCC using DTI. Major results of this study were: 1) There was no significant change in liver IQ with increased NED (P>0.05), whereas the liver IQ decreased significantly with increased B values (P<0.05); 2) NED=9 and B value = 500s/mm2 were chosen as the optimal set of parameters for liver; 3) Using the new optimized DTI sequence, ADC value of HCC lesions were significantly lower than those of normal right liver (1.30+ 0.34 vs 1.52+ 0.2710−3mm2/s, P=0.013) and the mean FA value of HCC lesions was significantly higher than normal right liver (0.42+ 0.11vs 0.32 + 0.10, P=0.004). Results demonstrate that the diffusion in HCC lesions should be restricted and anisotropic, which points out low ADC value and high FA value provide useful information about celluar changes induced by HCC, therefore, DTI can detect cellular changes induced by HCC in a typical clinical setting, HCC lead to higher FA values and lower ADCs on DTI than healthy liver.

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