Diffusion Tensor Imaging (DTI) in Liver Fibrosis with Minimal Confounding Effect of Hepatic Steatosis

Given the potential confounding effect of fat on apparent diffusion coefficient (ADC) in the liver in diffusion MRI, we have assessed diffusion tensor imaging (DTI) in liver fibrosis with minimal effect of fat on ADC and fractional anisotropy (FA) at 9.4T by employing a suitable animal model. Our results demonstrate that at b=0 and 500 s/mm2, FA may be more sensitive to mild-to-moderate liver fibrosis than ADC. In addition to ADC as demonstrated elsewhere, FA may also be sensitive to hepatic fat content, and therefore need to be carefully interpreted in the presence of fatty liver.

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