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Abstract #4113

Mapping Murine Diabetic Nephropathy: QMT, CEST and Fat Imaging

Feng Wang 1,2 , Ke Li 1,2 , Keiko Takahashi 3,4 , E. Brian Welch 1,2 , Zhongliang Zu 1,2 , Daniel Gochberg 1,2 , Raymond C. Harris 3,4 , C. Chad Quarles 1,2 , Takamune Takahashi 3,4 , and John C. Gore 1,2

1 Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 2 Institute of Imaging Sciences, Vanderbilt University, Nashville, TN, United States, 3 Vanderbilt O'Brien Mouse Kidney Physiology and Disease Center, Vanderbilt University, TN, United States, 4 Division of Nephrology and Hypertension, Vanderbilt University, TN, United States

Diabetic nephropathy (DN) is the leading cause of renal failure. Murine models of DN are routinely used to evaluate the mechanistic aspects of this disease. The objective of this study was to 1) validate and evaluate the reproducibility of quantitative magnetization transfer (qMT), chemical exchange saturation transfer (CEST) and fat imaging at 7T for assessing diabetic kidney disease and 2) determine the potential of these quantitative MRI approaches to distinguish moderate and advanced DN. The long-term goal is to understand the development and progression of fibrosis and lipid and glucose deposition in accelerated diabetic kidney disease.

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