Abstract #4114
Effects of a Western diet on fetal organ development and fat deposition using MRI of fetal guinea pigs
Kevin J Sinclair 1 , Lanette J Friesen-Waldner 1 , Colin M McCurdy 1 , Curtis N Wiens 2 , Trevor P Wade 1,3 , Barbra de Vrijer 4 , Timothy RH Regnault 4,5 , and Charles A McKenzie 1,3
1
Medical Biophysics, University of Western
Ontario, London, Ontario, Canada,
2
Radiology,
University of Wisconsin, Madison, Wisconsin, United
States,
3
Robarts Research Institute,
University of Western Ontario, London, Ontario, Canada,
4
Obstetrics
and Gynaecology, University of Western Ontario, London,
Ontario, Canada,
5
Physiology
and Pharmacology, University of Western Ontario, London,
Ontario, Canada
Over-nourishment of a fetus during development has been
shown to increase the risk of metabolic and
cardiovascular disease in adulthood. The purpose of this
study was to identify anatomical differences between
fetal guinea pigs subjected to a maternal Western Diet
and a synthetic Control Diet. T
1
- and T
2
-weighted,
as well as IDEAL water-fat images of pregnant guinea
pigs (N = 12) were used to obtain fetal organ volumes
and quantify fetal fat deposition. Western Diet fetuses
were seen to have increased liver volume and increased
fat deposition in the liver and in adipose tissue
compared to controls.
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