Abstract #4115
Alterations in the hepatic lipid profile of mice following streptozotocin-induced diabetes
Ana Francisca Soares 1 , Hongxia Lei 2 , and Rolf Gruetter 1
1
LIFMET, EPFL, Lausanne, Vaud, Switzerland,
2
Radiology,
University of Geneva, Geneva, Geneva, Switzerland
Hepatic lipids of healthy and streptozotocin-diabetic
mice were characterized by
1
H-MRS
in
vivo
with
ultra-short TE STEAM at 14.1T and compared to HR-MR
measurements of liver extracts, which were strongly
driven by membrane lipids. Streptozotocin injection
reduced the hepatic lipid content by over one half,
doubled the contribution saturated fatty-acyl (SFA)
chains, and decreased the mean length of the lipid
chains in the cytosolic pool. Membrane lipids were also
enriched with SFA and shorter chains. These alterations
are in line with abnormalities on lipid desaturation and
elongation in streptozotocin-diabetic mice.
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