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Abstract #4115

Alterations in the hepatic lipid profile of mice following streptozotocin-induced diabetes

Ana Francisca Soares 1 , Hongxia Lei 2 , and Rolf Gruetter 1

1 LIFMET, EPFL, Lausanne, Vaud, Switzerland, 2 Radiology, University of Geneva, Geneva, Geneva, Switzerland

Hepatic lipids of healthy and streptozotocin-diabetic mice were characterized by 1 H-MRS in vivo with ultra-short TE STEAM at 14.1T and compared to HR-MR measurements of liver extracts, which were strongly driven by membrane lipids. Streptozotocin injection reduced the hepatic lipid content by over one half, doubled the contribution saturated fatty-acyl (SFA) chains, and decreased the mean length of the lipid chains in the cytosolic pool. Membrane lipids were also enriched with SFA and shorter chains. These alterations are in line with abnormalities on lipid desaturation and elongation in streptozotocin-diabetic mice.

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