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Abstract #4116

Quantification of Hepatic Blood Flow in Obese Patients using 4D-flow MRI

Alejandro Roldn-Alzate 1 , Curtis N Wiens 1 , Kevin M Johnson 2 , Alan B Mcmillan 1 , Oliver Wieben 1,2 , Claude Sirlin 3 , and Scott B Reeder 1,2

1 Radiology, University of Wisconsin - Madison, Madison, WI, United States, 2 Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 3 Radiology, University of California San Diego, San Diego, CA, United States

NAFLD is an increasingly prevalent condition often encountered in patients with obesity. It is the most common type of chronic liver disease and a large and increasing number of NAFLD patients develop liver cirrhosis. In this study we evaluated the feasibility and describe preliminary observations of 4D Flow MRI to non-invasively assess portal hemodynamics in obese patients. Results show blood flow through Ao, PV and HA to be lower in obese patients than in healthy controls. The ability to non-invasively quantify mesenteric hemodynamics in these individuals suggests that 4D flow MRI may be suitable for use in future mechanistic studies of NAFLD pathogenesis, evolution, and response to therapeutic intervention.

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