Quantification of Hepatic Blood Flow in Obese Patients using 4D-flow MRI
Alejandro Roldn-Alzate 1 , Curtis N Wiens 1 , Kevin M Johnson 2 , Alan B Mcmillan 1 , Oliver Wieben 1,2 , Claude Sirlin 3 , and Scott B Reeder 1,2
Radiology, University of Wisconsin -
Madison, Madison, WI, United States,
Physics, University of Wisconsin - Madison, Madison, WI,
Radiology, University of
California San Diego, San Diego, CA, United States
NAFLD is an increasingly prevalent condition often
encountered in patients with obesity. It is the most
common type of chronic liver disease and a large and
increasing number of NAFLD patients develop liver
cirrhosis. In this study we evaluated the feasibility
and describe preliminary observations of 4D Flow MRI to
non-invasively assess portal hemodynamics in obese
patients. Results show blood flow through Ao, PV and HA
to be lower in obese patients than in healthy controls.
The ability to non-invasively quantify mesenteric
hemodynamics in these individuals suggests that 4D flow
MRI may be suitable for use in future mechanistic
studies of NAFLD pathogenesis, evolution, and response
to therapeutic intervention.
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