Abstract #4118
Relationship between liver proton density fat fraction and R2* in the absence of iron overload
Diego Hernando 1 , William M. Haufe 2 , Catherine A. Hooker 2 , Alexandra Schlein 2 , Tanya Wolfson 3 , Nathan S. Artz 1,4 , Scott B. Reeder 1,5 , and Claude B. Sirlin 2
1
Radiology, University of Wisconsin-Madison,
Madison, WI, United States,
2
Radiology,
University of California, San Diego, San Diego, CA,
United States,
3
Computational and Applied
Statistics Laboratory, University of California, San
Diego, San Diego, CA, United States,
4
Radiological
Sciences, Saint Jude Children's Research Hospital,
Memphis, TN, United States,
5
Medical
Physics, University of Wisconsin-Madison, Madison, WI,
United States
Chemical shift encoded techniques enable rapid fat and
iron quantification over the entire liver, by mapping
proton density fat fraction (PDFF) and R2* (=1/T2*),
respectively. However, the relationship between liver
PDFF and R2* in the absence of iron overload is not yet
fully understood. The purpose of this study was to
evaluate the relationship between liver PDFF and R2* in
patients with histology-confirmed absence of iron
overload. This works demonstrates a strong (r~0.8)
correlation between liver PDFF and R2* in patients
without iron overload. Future work is needed to fully
characterize the source of this correlation.
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