Abstract #4119
Optimization of Ectopic Lipids Determination in Kidneys by MRS and Preliminary Results in Obese Diabetic Patients.
Galle Diserens 1 , Maryam Seif 1 , Laila Yasmin Mani 2 , Daniel Fuster 2 , Christoph Stettler 3 , Chris Boesch 1 , Bruno Vogt 2 , and Peter Vermathen 1
1
Depts. Radiology and Clinical Research,
University Bern, Bern, Switzerland,
2
Dept.
Nephrology, Hypertension and Clinical Pharmacology,
University Hospital Of Bern, Bern, Switzerland,
3
Division
of Endocrinology, Diabetes and Clinical Nutrition,
Inselspital Bern, Bern, Switzerland
The purpose of this study was 1) to optimize the MRS
protocol for estimating ectopic renal lipids, 2) to
determine in a pilot study the ectopic lipid content in
obese patients with type 2 diabetes with the optimized
protocol. The preliminary SVS results in obese patients
with type 2 diabetes yielded ectopic lipid contributions
of only 0.80.4%. Reliable fat estimations in renal
tissue were obtained using a protocol optimized for
ectopic lipid determination. The finding of low ectopic
lipid content in few obese diabetic patients requires
confirmation.
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