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Abstract #4119

Optimization of Ectopic Lipids Determination in Kidneys by MRS and Preliminary Results in Obese Diabetic Patients.

Galle Diserens 1 , Maryam Seif 1 , Laila Yasmin Mani 2 , Daniel Fuster 2 , Christoph Stettler 3 , Chris Boesch 1 , Bruno Vogt 2 , and Peter Vermathen 1

1 Depts. Radiology and Clinical Research, University Bern, Bern, Switzerland, 2 Dept. Nephrology, Hypertension and Clinical Pharmacology, University Hospital Of Bern, Bern, Switzerland, 3 Division of Endocrinology, Diabetes and Clinical Nutrition, Inselspital Bern, Bern, Switzerland

The purpose of this study was 1) to optimize the MRS protocol for estimating ectopic renal lipids, 2) to determine in a pilot study the ectopic lipid content in obese patients with type 2 diabetes with the optimized protocol. The preliminary SVS results in obese patients with type 2 diabetes yielded ectopic lipid contributions of only 0.80.4%. Reliable fat estimations in renal tissue were obtained using a protocol optimized for ectopic lipid determination. The finding of low ectopic lipid content in few obese diabetic patients requires confirmation.

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