Abstract #4120
Modulation of ectopic fat and SCD activity during weight loss interventions in high saturated fat diet induced obese rats by in-vivo MRS and LC-MS
Venkatesh Gopalan 1 , Navin Michael 2 , S S Lee 1 , Yaligar J 1 , Bhanu Prakash KN 1 , and S Sendhil Velan 1
1
Singapore Bio-Imaging Consortium, BioMedical
Sciences Institutes, Singapore, Singapore,
2
Singapore
Institute for Clinical Sciences, Singapore, Singapore
Saturated fatty acids promote increased energy
partitioning towards fat storage, and reduced fat
oxidation, which is marked by increased stearoyl
coenzyme desaturase (SCD) activity and increased ectopic
fat infiltration. Both the above changes are strongly
linked to the pathogenesis of cardio-metabolic
disorders. In the current study we have evaluated the
relative effects of exercise and calorie restriction
interventions on weight loss, liver fat,
intramyocellular lipids in the skeletal muscle and SCD
activity in obese male rats fed with a high saturated
fat diet, using 1H magnetic resonance spectroscopy and
Liquid Chromatography-Mass Spectrometry (LC-MS).
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
