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Abstract #4120

Modulation of ectopic fat and SCD activity during weight loss interventions in high saturated fat diet induced obese rats by in-vivo MRS and LC-MS

Venkatesh Gopalan 1 , Navin Michael 2 , S S Lee 1 , Yaligar J 1 , Bhanu Prakash KN 1 , and S Sendhil Velan 1

1 Singapore Bio-Imaging Consortium, BioMedical Sciences Institutes, Singapore, Singapore, 2 Singapore Institute for Clinical Sciences, Singapore, Singapore

Saturated fatty acids promote increased energy partitioning towards fat storage, and reduced fat oxidation, which is marked by increased stearoyl coenzyme desaturase (SCD) activity and increased ectopic fat infiltration. Both the above changes are strongly linked to the pathogenesis of cardio-metabolic disorders. In the current study we have evaluated the relative effects of exercise and calorie restriction interventions on weight loss, liver fat, intramyocellular lipids in the skeletal muscle and SCD activity in obese male rats fed with a high saturated fat diet, using 1H magnetic resonance spectroscopy and Liquid Chromatography-Mass Spectrometry (LC-MS).

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