Abstract #4120
Modulation of ectopic fat and SCD activity during weight loss interventions in high saturated fat diet induced obese rats by in-vivo MRS and LC-MS
Venkatesh Gopalan 1 , Navin Michael 2 , S S Lee 1 , Yaligar J 1 , Bhanu Prakash KN 1 , and S Sendhil Velan 1
1
Singapore Bio-Imaging Consortium, BioMedical
Sciences Institutes, Singapore, Singapore,
2
Singapore
Institute for Clinical Sciences, Singapore, Singapore
Saturated fatty acids promote increased energy
partitioning towards fat storage, and reduced fat
oxidation, which is marked by increased stearoyl
coenzyme desaturase (SCD) activity and increased ectopic
fat infiltration. Both the above changes are strongly
linked to the pathogenesis of cardio-metabolic
disorders. In the current study we have evaluated the
relative effects of exercise and calorie restriction
interventions on weight loss, liver fat,
intramyocellular lipids in the skeletal muscle and SCD
activity in obese male rats fed with a high saturated
fat diet, using 1H magnetic resonance spectroscopy and
Liquid Chromatography-Mass Spectrometry (LC-MS).
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
