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Abstract #4121

Modulation of the abdominal and hepatic fat by adipose-specific fat-storage inducing transmembrane2 (FIT2) protein

Jadegoud Yaligar 1 , Bhanu Prakash KN 1 , Brayn Tan 2 , Swee Shean Lee 1 , Venkatesh Gopalan 1 , David Lawrence Silver 2 , and S Sendhil Velan 1

1 Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore, Singapore, 2 Signature Research Program in Cardiovascular & Met, Duke-NUS Graduate Medical School Singapore, Singapore, Singapore

Fat deposition in the body can be regulated by silencing the fat storage-inducing transmembrane (FIT) proteins. In our current study we have evaluated the abdominal and hepatic fat in both adipose-specific fat storage inducing transmembrane knockout (AFIT2KO) and their littermate (LL) control groups. Our results show that silencing of the AFIT2 protein specifically reduced the fat accumulation in adipose tissue whereas increased the fat accumulation in liver of AFIT2KO mice. Modulation (either down regulation or silencing) of these proteins might be of potential for drug discovery for obesity and type 2 diabetes

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