Abstract #4121
Modulation of the abdominal and hepatic fat by adipose-specific fat-storage inducing transmembrane2 (FIT2) protein
Jadegoud Yaligar 1 , Bhanu Prakash KN 1 , Brayn Tan 2 , Swee Shean Lee 1 , Venkatesh Gopalan 1 , David Lawrence Silver 2 , and S Sendhil Velan 1
1
Laboratory of Molecular Imaging, Singapore
Bioimaging Consortium, Singapore, Singapore, Singapore,
2
Signature
Research Program in Cardiovascular & Met, Duke-NUS
Graduate Medical School Singapore, Singapore, Singapore
Fat deposition in the body can be regulated by silencing
the fat storage-inducing transmembrane (FIT) proteins.
In our current study we have evaluated the abdominal and
hepatic fat in both adipose-specific fat storage
inducing transmembrane knockout (AFIT2KO) and their
littermate (LL) control groups. Our results show that
silencing of the AFIT2 protein specifically reduced the
fat accumulation in adipose tissue whereas increased the
fat accumulation in liver of AFIT2KO mice. Modulation
(either down regulation or silencing) of these proteins
might be of potential for drug discovery for obesity and
type 2 diabetes
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