Abstract #4122

Metabolic Adaptations Induced by Medium Chain Triglycerides in a Rat model of Diabetes Measured by in vivo Magnetic Resonance Spectroscopy

Lihong Jiang ¹ , Zejian Liu ² , Bei Wang ¹ , Greame Mason ^1,3 , Douglas Rothman ¹ , and Raimund Herzog ²

¹ Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, United States, ² Internal Medicine, Yale University School of Medicine, New Haven, CT, United States, ³ Psychiatry, Yale University School of Medicine, New Haven, CT, United States

Medium chain triglycerides (MCTs) have been used for treating food absorption disorders and digestive diseases, and have been shown increase glucose sensitivity in diabetic patients. We have investigated the metabolic adaptations in STZ-treated diabetic rats fed with a MCT-enriched diet, using in vivo magnetic resonance spectroscopy and metabolic modeling with infusions of [2,4- ¹³ C ₂ ] lower case Greek beta

-hydroxyl-butyrate (BHB) under a hyperinsulinemic hypoglycemic clamp. We have found that MCT diet decreased BHB uptake in astrocytes and increased glucose oxidation in neurons. The results were confirmed with qPCR technique. Our results suggest that MCT diet may not help to increase brain energy supply under acute hypoglycemia without antecedent recurrent hypoglycemia.

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