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Abstract #4123

Intranasal insulin improves energy metabolism in humans

Alessandra Bierwagen 1,2 , Sofiya Gancheva 1,2 , Chrysi Koliaki 1,2 , Peter Nowotny 1,2 , Jesper Lundbom 1,2 , Martin Heni 3,4 , Andreas Fritsche 3,4 , Hans-Ulrich Hring 3,4 , Julia Szendroedi 1,5 , and Michael Roden 1,5

1 Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research, Heinrich Heine University, Duesseldorf, Germany, 2 German Center for Diabetes Research (DZD e.V.), Partner Dsseldorf, Duesseldorf, Germany, 3 Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and, Eberhard Karls University, Tbingen, Germany, 4 Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Univer, Germany, 5 Department of Endocrinology and Diabetology, University Hospital, Duesseldorf, Germany

This study investigates the acute effects of central insulin on hepatic ATP and Pi content in healthy humans. Eight lean humans (262 yrs, BMI 231 kg/m2) received intranasal insulin (INI), intravenous insulin (IVI) and placebo. 31 P spectra of the human liver were acquired before and 3h after administration. The liver ATP concentration increased by 25.7 23.5% 3h after INI (p = .02), while it remains constant after IVI and placebo. In conclusion, intranasal insulin application can improve hepatic energy metabolism in healthy humans.

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