Abstract #4123
Intranasal insulin improves energy metabolism in humans
Alessandra Bierwagen 1,2 , Sofiya Gancheva 1,2 , Chrysi Koliaki 1,2 , Peter Nowotny 1,2 , Jesper Lundbom 1,2 , Martin Heni 3,4 , Andreas Fritsche 3,4 , Hans-Ulrich Hring 3,4 , Julia Szendroedi 1,5 , and Michael Roden 1,5
1
Institute for Clinical Diabetology, German
Diabetes Center, Leibniz Institute for Diabetes
Research, Heinrich Heine University, Duesseldorf,
Germany,
2
German Center for Diabetes Research
(DZD e.V.), Partner Dsseldorf, Duesseldorf, Germany,
3
Department
of Internal Medicine, Division of Endocrinology,
Diabetology, Angiology, Nephrology and, Eberhard Karls
University, Tbingen, Germany,
4
Institute
for Diabetes Research and Metabolic Diseases of the
Helmholtz Center Munich at the Univer, Germany,
5
Department
of Endocrinology and Diabetology, University Hospital,
Duesseldorf, Germany
This study investigates the acute effects of central
insulin on hepatic ATP and Pi content in healthy humans.
Eight lean humans (262 yrs, BMI 231 kg/m2) received
intranasal insulin (INI), intravenous insulin (IVI) and
placebo.
31
P
spectra of the human liver were acquired before and 3h
after administration. The liver ATP concentration
increased by 25.7 23.5% 3h after INI (p = .02), while
it remains constant after IVI and placebo. In
conclusion, intranasal insulin application can improve
hepatic energy metabolism in healthy humans.
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