A New 3D Isotropic T 1 Mapping Technique for In Vivo Human Knee Cartilage at 7T MRI
Guruprasad Krishnamoorthy 1 , Puneet Bagga 1 , Ravi Prakash Reddy Nanga 1 , Hari Hariharan 1 , John Bruce Kneeland 2 , and Ravinder Reddy 1
Center for Magnetic Resonance and Optical
Imaging, University of Pennsylvania, Philadelphia, PA,
of Radiology, University of Pennsylvania, Philadelphia,
PA, United States
Osteoarthritis (OA) is a degenerative disease affecting
Articular Cartilage (AC) of synovial joints like knee,
shoulder, hip, etc. Spin-lattice relaxation in the
rotating frame (T1ρ) has been a promising quantitative
MRI technique to detect biochemical changes in the AC.
High resolution MRI is desired across the thickness of
AC particularly in the OA subjects to identify the
extent of the cartilage degeneration. Here we propose a
new 3D-GRE based time efficient method to acquire T1ρ
weighted images of the whole knee at an isotropic
resolution that allows the reformatting of the isotropic
images of knee to any desired orientation.
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