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Abstract #4168

A New 3D Isotropic T 1 Mapping Technique for In Vivo Human Knee Cartilage at 7T MRI

Guruprasad Krishnamoorthy 1 , Puneet Bagga 1 , Ravi Prakash Reddy Nanga 1 , Hari Hariharan 1 , John Bruce Kneeland 2 , and Ravinder Reddy 1

1 Center for Magnetic Resonance and Optical Imaging, University of Pennsylvania, Philadelphia, PA, United States, 2 Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Osteoarthritis (OA) is a degenerative disease affecting Articular Cartilage (AC) of synovial joints like knee, shoulder, hip, etc. Spin-lattice relaxation in the rotating frame (T1ρ) has been a promising quantitative MRI technique to detect biochemical changes in the AC. High resolution MRI is desired across the thickness of AC particularly in the OA subjects to identify the extent of the cartilage degeneration. Here we propose a new 3D-GRE based time efficient method to acquire T1ρ weighted images of the whole knee at an isotropic resolution that allows the reformatting of the isotropic images of knee to any desired orientation.

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