Abstract #4184
Multiparametric MRI Assessment of Necrotic Epiphyseal Cartilage Induced by Transection of Cartilage Canal Blood Vessels in Goat Kids
Luning Wang 1 , Mikko J Nissi 2 , Ferenc Toth 3 , Michael Garwood 1 , Cathy Carlson 3 , and Jutta Ellermann 1
1
Center for Magnetic Resonance Research,
University of Minnesota, Twin Cities, Minneapolis, MN,
United States,
2
Medical
Research Center Oulu, Oulu University Hospital and
University of Oulu, Finland,
3
University
of Minnesota, Twin Cities, Minneapolis, MN, United
States
Juvenile Osteochondritis Dissecans (OCD) is an
orthopaedic disease of children and young adults that
may result in significant lifelong disabilities. The
etiology is likely related to ischemic vascular events
and subsequent epiphyseal cartilage necrosis occuring
during skeletal maturation, but is poorly understood. In
this work, we present multiparametric relaxation time
mapping and histology of epiphyseal cartilage in a goat
model of surgically-induced ischemia at different stages
of lesion development. T1, T2, (CW) T1ρ, adiabatic T1ρ
and TRAFF provided a sensitive, noninvasive way to
detect ischemic necrosis. These noninvasive MR methods
are promising both for staging lesion development and
for outcome assessment after intervention in children
with OCD.
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