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Abstract #4184

Multiparametric MRI Assessment of Necrotic Epiphyseal Cartilage Induced by Transection of Cartilage Canal Blood Vessels in Goat Kids

Luning Wang 1 , Mikko J Nissi 2 , Ferenc Toth 3 , Michael Garwood 1 , Cathy Carlson 3 , and Jutta Ellermann 1

1 Center for Magnetic Resonance Research, University of Minnesota, Twin Cities, Minneapolis, MN, United States, 2 Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Finland, 3 University of Minnesota, Twin Cities, Minneapolis, MN, United States

Juvenile Osteochondritis Dissecans (OCD) is an orthopaedic disease of children and young adults that may result in significant lifelong disabilities. The etiology is likely related to ischemic vascular events and subsequent epiphyseal cartilage necrosis occuring during skeletal maturation, but is poorly understood. In this work, we present multiparametric relaxation time mapping and histology of epiphyseal cartilage in a goat model of surgically-induced ischemia at different stages of lesion development. T1, T2, (CW) T1ρ, adiabatic T1ρ and TRAFF provided a sensitive, noninvasive way to detect ischemic necrosis. These noninvasive MR methods are promising both for staging lesion development and for outcome assessment after intervention in children with OCD.

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