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Abstract #4185

Water-selective 3D bSSFP imaging of biomaterials promoting bone repair in rats; Comparison with micro-CT

Emeline Julie Ribot 1 , Clment Tournier 2 , Aurlien Julien Trotier 1 , Didier Wecker 3 , Didier Letourneur 4 , Joelle Amde 2 , and Sylvain Miraux 1

1 RMSB - UMR5536, CNRS - University Bordeaux, Bordeaux, France, Metropolitan, 2 Biotis - U1026, INSERM - University Bordeaux, Bordeaux, France, Metropolitan, 3 Bruker Biospin GmbH, Ettlingen, Germany, 4 LRVT - UMR1148, INSERM - University Paris 7, Paris, France, Metropolitan

The conventional imaging method to follow bone repair is based on X-ray. To circumvent repetitive irradiation exposures, a MRI 3D bSSFP sequence was performed longitudinally on rats with biomaterials implanted in femoral condyle bone defects. Due to the insertion of a water-selective binomial radiofrequency pulse, the signal from adipose tissue within the bone marrow dropped, allowing the visualization of the biomaterials with hyperintense signal. Thus, their volumes were measured precisely over time. Their degradations corresponded with bone regeneration observed on ex vivo micro-CT.

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