Abstract #4185
Water-selective 3D bSSFP imaging of biomaterials promoting bone repair in rats; Comparison with micro-CT
Emeline Julie Ribot 1 , Clment Tournier 2 , Aurlien Julien Trotier 1 , Didier Wecker 3 , Didier Letourneur 4 , Joelle Amde 2 , and Sylvain Miraux 1
1
RMSB - UMR5536, CNRS - University Bordeaux,
Bordeaux, France, Metropolitan,
2
Biotis
- U1026, INSERM - University Bordeaux, Bordeaux, France,
Metropolitan,
3
Bruker
Biospin GmbH, Ettlingen, Germany,
4
LRVT
- UMR1148, INSERM - University Paris 7, Paris, France,
Metropolitan
The conventional imaging method to follow bone repair is
based on X-ray. To circumvent repetitive irradiation
exposures, a MRI 3D bSSFP sequence was performed
longitudinally on rats with biomaterials implanted in
femoral condyle bone defects. Due to the insertion of a
water-selective binomial radiofrequency pulse, the
signal from adipose tissue within the bone marrow
dropped, allowing the visualization of the biomaterials
with hyperintense signal. Thus, their volumes were
measured precisely over time. Their degradations
corresponded with bone regeneration observed on ex vivo
micro-CT.
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