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Abstract #4186

7T MRI of Trabecular Microarchitecture at the Distal Radius: How Bone Quality Varies at the Epiphysis, Metaphysis, and Diaphysis

Lindsay M Griffin 1 , Stephen Honig 2 , Yinxiao Liu 3 , Cheng Chen 3 , Punam K Saha 3 , Ravinder Regatte 1 , and Gregory Chang 1

1 Department of Radiology, New York University School of Medicine, New York, New York, United States, 2 Department of Medicine, New York University, New York, United States, 3 University of Iowa, Iowa, United States

This study utilized 7T MRI at the distal radius to describe how microarchitectural parameters vary depending upon distance from the end-of-bone and the relationship between microarchitectual parameters at the diaphysis, epiphysis, and metaphysis. Quality of trabecular microarchitecture appears to be greatest at the epiphysis and lowest at the diaphysis. While bone volume and trabecular connectivity were highly correlated with trabecular number at all sites, the association of trabecular network resorption (a measure of bone resorption by osteoclasts) with other measures of microarchitecture was significant in the metaphysis and epiphysis only. Future study includes how site and parameters relate to fracture risk or response to treatment.

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