Abstract #4186
7T MRI of Trabecular Microarchitecture at the Distal Radius: How Bone Quality Varies at the Epiphysis, Metaphysis, and Diaphysis
Lindsay M Griffin 1 , Stephen Honig 2 , Yinxiao Liu 3 , Cheng Chen 3 , Punam K Saha 3 , Ravinder Regatte 1 , and Gregory Chang 1
1
Department of Radiology, New York University
School of Medicine, New York, New York, United States,
2
Department
of Medicine, New York University, New York, United
States,
3
University
of Iowa, Iowa, United States
This study utilized 7T MRI at the distal radius to
describe how microarchitectural parameters vary
depending upon distance from the end-of-bone and the
relationship between microarchitectual parameters at the
diaphysis, epiphysis, and metaphysis. Quality of
trabecular microarchitecture appears to be greatest at
the epiphysis and lowest at the diaphysis. While bone
volume and trabecular connectivity were highly
correlated with trabecular number at all sites, the
association of trabecular network resorption (a measure
of bone resorption by osteoclasts) with other measures
of microarchitecture was significant in the metaphysis
and epiphysis only. Future study includes how site and
parameters relate to fracture risk or response to
treatment.
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