Abstract #4192
Bone Curvature Changes of the Knee in OA Subjects as on Detected on MRI Can Predict Who Will Progress to TKR in Five Years Time: Data From the OAI
Joshua Michael Farber 1 , Jose Tamez-Pena 2 , David Hunter 3 , Michael Hannon 4 , Saara Totterman 5 , Zhijie Wang 6 , Robert Boudreau 7 , and Kent Kowh 8
1
Radiology, Qmetrics Technologies,
Cincinnati, Ohio, United States,
2
Imaging
Sciences, Escuela de Medicina, Tec de Monterray,
Monterray, Monterray, Mexico,
3
Rheumatology,
Royal North Shore Hosp. and Northern Clinical Sch, Univ.
of Sydney, Sydney, Sydney, Australia,
4
Epidemiology,
Dept. of Epidemiology, Univ. of Pittsburgh, Pittsburgh,
Pennsylvania, United States,
5
Radiology,
Qmetrics Technologies, Rochester, New York, United
States,
6
Dept.
of Epidemiology, Univ. of Pittsburgh, Pittsburgh,
Pennsylvania, United States,
7
Epidemiology,
dept. of Epidemiology, Univ. of Pittsburgh, Pittsburgh,
Pennsylvania, United States,
8
Rheumatology,
The University of Arizona, Arthritis Center, Tuscon,
Arizona, United States
This work analyzes knee bone curvature from OAI data
sets in patients with OA and predicts which subjects
will advance to TKR within five years of the initial
imaging. The MRI analysis is correlated with KL scores
and all TKR subjects are compared with match controls
who do not advance to TKR. The result is the development
of a biomarker, based on MRI bone curvatre changes, for
end-stage knee OA as defined by the need for TKR.
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