Abstract #4191
Intermittent Parathyroid hormone treatment reduces scar tissue formation at the proximity of calvarial grafts, demonstrate by collagen-sensitive MRI scanning methods
Doron Cohn Yakubovich 1 , Uzi Eliav 2 , Gadi Pelled 1,3 , Dan Gazit 1,3 , Zulma Gazit 1,3 , and Gil Navon 2
1
Skeletal Biotech Laboratory, Hebrew
University of Jerusalem, Jerusalem, Israel, Israel,
2
School
of Chemistry, Tel Aviv University, Tel Aviv, Israel,
Israel,
3
Department of Surgery and
Cedars-Sinai Regenerative Medicine Institute,
Cedars-Sinai Medical Center, Los Angeles, California,
United States
Calvarial bone grafts often fail to integrate due scar
tissue formation at the grafts proximity. In order to
examine parathyroid hormone (PTH, a bone anabolic agent)
effect on the extent of scaring, we used MTC and the
magnetization exchange μMRI scanning protocol, MEX. The
results show that μMRI reveals changes in the extent of
scaring and bone formation as a result of the PTH
administration in comparison to the control animals,
enabling differentiation between new bone formation and
scar tissue. Our technique will enable clinical
longitudinal, non-invasive follow up of various fibrosis
related conditions.
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