Meeting Banner
Abstract #4191

Intermittent Parathyroid hormone treatment reduces scar tissue formation at the proximity of calvarial grafts, demonstrate by collagen-sensitive MRI scanning methods

Doron Cohn Yakubovich 1 , Uzi Eliav 2 , Gadi Pelled 1,3 , Dan Gazit 1,3 , Zulma Gazit 1,3 , and Gil Navon 2

1 Skeletal Biotech Laboratory, Hebrew University of Jerusalem, Jerusalem, Israel, Israel, 2 School of Chemistry, Tel Aviv University, Tel Aviv, Israel, Israel, 3 Department of Surgery and Cedars-Sinai Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States

Calvarial bone grafts often fail to integrate due scar tissue formation at the grafts proximity. In order to examine parathyroid hormone (PTH, a bone anabolic agent) effect on the extent of scaring, we used MTC and the magnetization exchange μMRI scanning protocol, MEX. The results show that μMRI reveals changes in the extent of scaring and bone formation as a result of the PTH administration in comparison to the control animals, enabling differentiation between new bone formation and scar tissue. Our technique will enable clinical longitudinal, non-invasive follow up of various fibrosis related conditions.

This abstract and the presentation materials are available to members only; a login is required.

Join Here