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Abstract #4198

Comparison of Relaxation-Based NMR Methods for Quantifying Bound and Pore Bone Water Fractions

Alan C. Seifert 1 , Suzanne L. Wehrli 2 , and Felix W. Wehrli 1

1 University of Pennsylvania, Philadelphia, PA, United States, 2 Children's Hospital of Philadelphia, Philadelphia, PA, United States

Increased cortical porosity is a major cause of the impaired strength of osteoporotic bone. MicroCT and gravimetry are accepted methods for validation of porosity and matrix density, but involve long scan times and destruction of specimens, respectively. In this work, we compare several NMR methods for quantification of bound and pore water (biomarkers for matrix density and porosity, respectively). T2 fitting of CPMG data at 9.4T outperforms T2* fitting of FIDs at 3T, while 2H IR at 9.4T performs approximately as well as T2* fitting. Incorporation of a second T1 dimension yields improved fidelity for both T2 and T2* fitting.

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