Abstract #4199
Cortical Bone Porosity: A Novel MRI-Based Clinical Biomarker to Assess Cortical Bone Quality In Vivo
Shahrokh Abbasi Rad 1,2 , Atena Akbari 1 , Niloofar Tondro 3 , Mohsen Shojaee-Moghaddam 3 , and Hamidreza Saligheh Rad 1,2
1
Quantitative MR Imaging and Spectroscopy
Group, Research Center for Molecular and Cellular
Imaging, Tehran University of Medical Sciences, Tehran,
Iran,
2
Medical
Physics and Biomedical Engineering Department, Tehran
University of Medical Sciences, Tehran, Iran,
3
Imaging
Center, Payambaran Hospital, Tehran, Iran
There exist three types of proton pools in the cortical
bone: loosely bonded to the collagen matrix, tightly
bonded to the minerals, and mobile protons residing in
the pores of cortical bone like Haversian canals,
lacunae and canaliculi. Mobile water can be considered
as a reliable determinant of cortical bone porosity. As
the porosity increases with age, we hypothesized that
mobile water concentration of the cortical bone must be
in good correlation with age, and investigated it using
a clinically available MRI pulse sequence named Short
Echo Time (STE), which employs echo-time in the range of
0.5 to 1.5 ms.
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