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Abstract #4199

Cortical Bone Porosity: A Novel MRI-Based Clinical Biomarker to Assess Cortical Bone Quality In Vivo

Shahrokh Abbasi Rad 1,2 , Atena Akbari 1 , Niloofar Tondro 3 , Mohsen Shojaee-Moghaddam 3 , and Hamidreza Saligheh Rad 1,2

1 Quantitative MR Imaging and Spectroscopy Group, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran, 2 Medical Physics and Biomedical Engineering Department, Tehran University of Medical Sciences, Tehran, Iran, 3 Imaging Center, Payambaran Hospital, Tehran, Iran

There exist three types of proton pools in the cortical bone: loosely bonded to the collagen matrix, tightly bonded to the minerals, and mobile protons residing in the pores of cortical bone like Haversian canals, lacunae and canaliculi. Mobile water can be considered as a reliable determinant of cortical bone porosity. As the porosity increases with age, we hypothesized that mobile water concentration of the cortical bone must be in good correlation with age, and investigated it using a clinically available MRI pulse sequence named Short Echo Time (STE), which employs echo-time in the range of 0.5 to 1.5 ms.

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