Abstract #4206
MR micro-neurography in the investigation of amyloid-related neuropathy
Paolo F Felisaz 1 , Eric Y Chang 2 , Polesel Marco 1 , Irene Carne 3 , Maugeri Giulia 1 , Giovanni Palladini 4 , Obici Laura 4 , Giampaolo Merlini 4 , Baldi Maurizia 5 , Stefano Bastianello 6 , and Fabrizio Calliada 1
1
Radiology Department, University of Pavia,
Pavia, Italy,
2
Radiology
Service, VA San Diego Healthcare System, San Diego, CA,
United States,
3
Medical
Physics Department, IRCCS Salvatore Maugeri Foundation,
Scientific Institute of Pavia, Italy,
4
Amyloid
Research and Treatment Center, Scientific Institute
Policlinico San Matteo, Pavia, Italy,
5
Radiology
Department, IRCCS Salvatore Maugeri Foundation,
Scientific Institute of Pavia, Italy,
6
Department
of Brain and Behavioral Sciences, University of Pavia,
Pavia, Italy
The aim of this study is to evaluate peripheral nerves
in amyloid-related neuropathy using high-resolution MRI.
A clinical 3T scanner with readily available sequences
and coils are used. Our MRI protocol allows spatial
resolution down to 100 μm, with demonstration of tissue
detail comparable with light microscopy after
histological staining. We evaluated 6 patients with
various grades of amyloid-related neuropathy of the
lower limbs. Amyloid neuropathy MR micro-neurograms
demonstrate an obvious pathologic pattern with increased
amounts of epineurial fat and decreased number of
fascicles. Early diagnosis of this neuropathy may impact
patient treatment and outcome.
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