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Abstract #4207

UTE-based Short-T2* Mapping and PLM Optical Imaging for Evaluating Disruption of Collagen Fibers in the Knee Cartilage Explants

Yongxian Qian 1 , Ashley A. Williams 2 , and Constance R. Chu 2

1 Qian's Lab for MRI, General Labs Cloud LLC, Pittsburgh, PA, United States, 2 Orthopaedic Surgery, Stanford University, Redwood City, CA, United States

Very initial testing results on human knee cartilage explants are presented to demonstrate the consistency in evaluation of collagen fiber disruption between noninvasive UTE-based short-T2* mapping and destructive imaging of polarized light microscopy (PLM). This consistency is suggestive of the potential of short component of transverse (T2) relaxation as an imaging biomarker for detecting disruption of collagen fibers in cartilage.

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