Abstract #4207
UTE-based Short-T2* Mapping and PLM Optical Imaging for Evaluating Disruption of Collagen Fibers in the Knee Cartilage Explants
Yongxian Qian 1 , Ashley A. Williams 2 , and Constance R. Chu 2
1
Qian's Lab for MRI, General Labs Cloud LLC,
Pittsburgh, PA, United States,
2
Orthopaedic
Surgery, Stanford University, Redwood City, CA, United
States
Very initial testing results on human knee cartilage
explants are presented to demonstrate the consistency in
evaluation of collagen fiber disruption between
noninvasive UTE-based short-T2* mapping and destructive
imaging of polarized light microscopy (PLM). This
consistency is suggestive of the potential of short
component of transverse (T2) relaxation as an imaging
biomarker for detecting disruption of collagen fibers in
cartilage.
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