Abstract #4207
            UTE-based Short-T2* Mapping and PLM Optical Imaging for Evaluating Disruption of Collagen Fibers in the Knee Cartilage Explants
                      Yongxian Qian                     1                    , Ashley A. Williams                     2                    , 						and Constance R. Chu                     2          
            
            1
           
           Qian's Lab for MRI, General Labs Cloud LLC, 
						Pittsburgh, PA, United States,
           
            2
           
           Orthopaedic 
						Surgery, Stanford University, Redwood City, CA, United 
						States
          
            
          Very initial testing results on human knee cartilage 
						explants are presented to demonstrate the consistency in 
						evaluation of collagen fiber disruption between 
						noninvasive UTE-based short-T2* mapping and destructive 
						imaging of polarized light microscopy (PLM). This 
						consistency is suggestive of the potential of short 
						component of transverse (T2) relaxation as an imaging 
						biomarker for detecting disruption of collagen fibers in 
						cartilage.
         
				
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