Quantifying perfusion in conditions of rapidly changing blood flow and vascular volume: A novel tracer kinetic model

DCE MRI is widely used for assessing tissue perfusion noninvasively, using indicator dilution theory, which models tissue enhancement as a convolution between the arterial input function and impulse response function. This approach requires that the system of interest is time-invariant during data acquisition, which is fulfilled in most situations. However, the convolution approach does not work when perfusion changes dramatically during the measurement period, such as skeletal muscle perfusion during exercise-recovery. In this study, we propose a new tracer kinetic model where both blood inflow and vascular volume can vary during the measurement.

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