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Abstract #4247

Multi parametric MRI evaluation of muscle development

Kerryanne V. Winters 1,2 , Olivier Reynaud 1,2 , Dmitry S. Novikov 1,2 , Els Fieremans 1,2 , and Sungheon G. Kim 1,2

1 Department of Radiology, Bernard and Irene Schwartz Center for Biomedical Imaging - NYU School of Medicine, New York, NY, United States, 2 Center for Advanced Imaging Innovation and Research, NYU Langone Medical Center, New York, NY, United States

We quantified changes in normal skeletal muscle growth using time dependent DTI combined with the random permeable barrier model (RPBM), the conventional IDEAL-Dixon imaging and T2 mapping. Muscle development was assessed by using different age of mice and comparing the parameters of each modality. DTI-RPBM was used to monitor changes in muscle fiber size and sarcolemma permeability, and showed that younger mice had higher surface-to-volume ratio and higher membrane permeability. Dixon imaging proved that with development, fatty deposits develop and therefore increase the fat fraction of the tissue. In addition, our preliminary results also showed that T2 values decrease with age. These results demonstrate that the microstructural changes measured using DTI-RPBM during muscle development are in line with the literature and can serve as a useful tool in assessment of disease progress or treatment response in various myopathies.

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