Abstract #4247
Multi parametric MRI evaluation of muscle development
Kerryanne V. Winters 1,2 , Olivier Reynaud 1,2 , Dmitry S. Novikov 1,2 , Els Fieremans 1,2 , and Sungheon G. Kim 1,2
1
Department of Radiology, Bernard and Irene
Schwartz Center for Biomedical Imaging - NYU School of
Medicine, New York, NY, United States,
2
Center
for Advanced Imaging Innovation and Research, NYU
Langone Medical Center, New York, NY, United States
We quantified changes in normal skeletal muscle growth
using time dependent DTI combined with the random
permeable barrier model (RPBM), the conventional
IDEAL-Dixon imaging and T2 mapping. Muscle development
was assessed by using different age of mice and
comparing the parameters of each modality. DTI-RPBM was
used to monitor changes in muscle fiber size and
sarcolemma permeability, and showed that younger mice
had higher surface-to-volume ratio and higher membrane
permeability. Dixon imaging proved that with
development, fatty deposits develop and therefore
increase the fat fraction of the tissue. In addition,
our preliminary results also showed that T2 values
decrease with age. These results demonstrate that the
microstructural changes measured using DTI-RPBM during
muscle development are in line with the literature and
can serve as a useful tool in assessment of disease
progress or treatment response in various myopathies.
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