Abstract #4248
Muscle perfusion reserve (MPR) measured from exercise-recovery MRI: a new functional index for diagnosing PAD
Jeff L Zhang 1 , Christopher J Hanrahan 1 , Jason Mendes 1 , Gwenael Layec 2 , Corey Hart 2 , Kristi Carlston 1 , Michelle Mueller 3 , Russell S Richardson 2 , and Vivian S Lee 1
1
Radiology, University of Utah, Salt Lake
City, Utah, United States,
2
Division
of Geriatrics, Department of Internal Medicine,
University of Utah, Salt Lake City, Utah, United States,
3
Vascular
Surgery, University of Utah, Salt Lake City, Utah,
United States
Without a reliable way of assessing calf muscle
function, therapeutic management of PAD is highly
controversial. None existing imaging is capable of
quantifying exercise-induced capillary recruitment. We
have applied a validated plantar-flexion exercise
protocol within MRI scanner together with ASL
measurements at exercise recovery to measure
exercise-induced capillary recruitment, which we term
Muscle Perfusion Reserve (MPR). We examined MPR in
healthy subjects. MPR increased as workloads.
Significant differences in MPR were found between the
two healthy subjects with different body mass index. The
proposed MPR has great potential of evaluating calf
muscle function of PAD and improving their therapeutic
management.
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