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Abstract #4248

Muscle perfusion reserve (MPR) measured from exercise-recovery MRI: a new functional index for diagnosing PAD

Jeff L Zhang 1 , Christopher J Hanrahan 1 , Jason Mendes 1 , Gwenael Layec 2 , Corey Hart 2 , Kristi Carlston 1 , Michelle Mueller 3 , Russell S Richardson 2 , and Vivian S Lee 1

1 Radiology, University of Utah, Salt Lake City, Utah, United States, 2 Division of Geriatrics, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States, 3 Vascular Surgery, University of Utah, Salt Lake City, Utah, United States

Without a reliable way of assessing calf muscle function, therapeutic management of PAD is highly controversial. None existing imaging is capable of quantifying exercise-induced capillary recruitment. We have applied a validated plantar-flexion exercise protocol within MRI scanner together with ASL measurements at exercise recovery to measure exercise-induced capillary recruitment, which we term Muscle Perfusion Reserve (MPR). We examined MPR in healthy subjects. MPR increased as workloads. Significant differences in MPR were found between the two healthy subjects with different body mass index. The proposed MPR has great potential of evaluating calf muscle function of PAD and improving their therapeutic management.

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