Abstract #4249
Evaluation of skeletal muscle DTI in Duchenne Muscular Dystrophy
Melissa Hooijmans 1 , Martijn Froeling 2 , Maarten Versluis 3 , Andrew Webb 1 , Erik Niks 4 , Jan Verschuuren 4 , and Hermien Kan 1
1
Radiology, Leiden University Medical Center,
Leiden, Zuid-holland, Netherlands,
2
Radiology,
Utrecht Medical Center, Utrecht, Netherlands,
3
Philips,
Netherlands,
4
Neurology,
Leiden University Medical Center, Leiden, Zuid-holland,
Netherlands
Skeletal muscle DTI can potentially serve as a surrogate
measure of fiber architecture. This intrinsically
T2-weighted sequence is susceptible to SNR and fat
percentage. In muscles of Duchenne muscular dystrophy
(DMD) patients, increased %fat and higher T2 relaxation
times could obscure pathophysiological effects on DTI
parameter estimation. Our data show that the proposed
quality criteria from simulation-based work are suited
to reliably determine mean diffusivity (MD) in DMD
patients and controls and that multi-parametric MRI is
essential to distinguish between confounding effects and
pathophysiological processes in skeletal muscle DTI.
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