Abstract #4250
Advanced pathology in aged mdx muscle characterized by quantitative multi-parametric MRI
Nathan David Bryant 1,2 , Ke Li 1,2 , and Bruce Damon 1,2
1
Vanderbilt University Institute of Imaging
Science, Vanderbilt University, Nashville, TN, United
States,
2
Department
of Radiology and Radiological Sciences, Vanderbilt
University, Nashville, TN, United States
Dystrophic skeletal muscles, from mdx mice of advanced
age and stages of myopathy, were characterized using an
array of quantitative metrics derived from a
multi-parametric MRI approach including: T2, DTI and
qMT-MRI data that were collected in a single imaging
session. These observations were compared to age matched
healthy control mice. Compared to healthy control
muscle, old mdx gastroc muscles were observed to have in
increased T2, but were not different in terms of the
diffusion indices investigated. However, the qMT
parameters R1f, PSR, and kmf were all decreased in the
histologically-verified fibrotic and advanced dystrophic
pathology mdx muscle.
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