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Abstract #4253

Muscle Oxygenation Changes in Different Bone Mineral Density Subjects - a BOLD Based Study

Heather T. Ma 1,2 , James F. Griffith 3 , Yang Chen 1 , Shoulin Huang 1 , Davd K. Yeung 3 , Xu Xing 1 , and Li Liang 1

1 Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong, China, 2 Johns Hopkins University, Baltimore, MD, United States, 3 The Chinese University of Hong Kong, Hong Kong, China

This study examined the BOLD effect on calf muscles in different bone mineral density (BMD) elderly females to investigate the oxygenation characteristics in osteoporotic patients. An air-cuff was used to induce ischemia and BOLD-MRI data was curve fitted to derive quantitative parameters. A significant decreased Slope during hyperemia and longer Half-life in ischemic stage were shown in the BOLD signal of subjects with lower BMD, indicating a different vascular reactivity and oxygen utilization strategy in osteoporotic patients. No significant changes of minimum ischemic value among subjects may indicate a normal oxygen utilization in total for osteoporotic patients.

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