Abstract #4253
Muscle Oxygenation Changes in Different Bone Mineral Density Subjects - a BOLD Based Study
Heather T. Ma 1,2 , James F. Griffith 3 , Yang Chen 1 , Shoulin Huang 1 , Davd K. Yeung 3 , Xu Xing 1 , and Li Liang 1
1
Harbin Institute of Technology Shenzhen
Graduate School, Shenzhen, Guangdong, China,
2
Johns
Hopkins University, Baltimore, MD, United States,
3
The
Chinese University of Hong Kong, Hong Kong, China
This study examined the BOLD effect on calf muscles in
different bone mineral density (BMD) elderly females to
investigate the oxygenation characteristics in
osteoporotic patients. An air-cuff was used to induce
ischemia and BOLD-MRI data was curve fitted to derive
quantitative parameters. A significant decreased Slope
during hyperemia and longer Half-life in ischemic stage
were shown in the BOLD signal of subjects with lower
BMD, indicating a different vascular reactivity and
oxygen utilization strategy in osteoporotic patients. No
significant changes of minimum ischemic value among
subjects may indicate a normal oxygen utilization in
total for osteoporotic patients.
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