Abstract #4252
Deformation-Induced Damage in Rat Skeletal Muscle: role of the vascular system
Jules Nelissen 1,2 , Willeke Traa 3 , Kevin Moerman 4 , Cees Oomens 3 , Aart Nederveen 4 , Klaas Nicolay 1 , and Gustav Strijkers 1,2
1
Biomedical NMR, Department of Biomedical
Engineering, Eindhoven University of Technology,
Eindhoven, Netherlands,
2
Biomedical
Engineering and Physics, Academic Medical Center,
Amsterdam, Netherlands,
3
Soft
Tissue Biomechanics and Engineering, Department of
Biomedical Engineering, Eindhoven University of
Technology, Eindhoven, Netherlands,
4
Department
of Radiology, Academic Medical Center, Amsterdam,
Netherlands
To investigate the response of the vascular system on
sustained mechanical loading of skeletal muscle and
subsequent skeletal muscle damage after end of period of
deformation a study was performed in a rat model for
skeletal muscle damage. During application of sustained
mechanical loading to skeletal muscle and subsequent
collapse of main supplying artery the body tries to keep
up blood supply. After end of indentation a hyperemic
response is observed. In case of combination of skeletal
muscle deformation and occlusion of main supplying
vessel, more edema formation is observed, which was
further confirmed by T2 ROI analysis. T2 enhancement due
to skeletal muscle damage appears highly structured and
matches the peri, and endomysium organization of
skeletal muscle.
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