Abstract #4256
Correlation between quantitative MRI features and functional assessment of myopathy
Hon J. Yu 1,2 , Manaswitha Khare 3 , Mathew Gargus 3 , Marie Wencel 3 , Abhilasha Surampalli 3 , Vince Caiozzo 4 , and Virginia Kimonis 3
1
Radiological Sciences, University of
California, Irvine, CA, United States,
2
Tu
& Yuen Center for Functional Onco-Imaging, University of
California, Irvine, CA, United States,
3
Pediatrics,
University of California, Irvine, CA, United States,
4
Orthopaedic
Surgery, University of California, Irvine, CA, United
States
MRI and biophysical evaluation were performed on eight
subjects consisting of control and patients with varying
degrees of myopathy. Despite small sample size, the
potential for quantitative MRI features based on texture
analysis is demonstrated as a functional means for
muscle function in comparison with dynamometer-based
muscle strength measurements, which could be an
invaluable tool in study of the disease progression
and/or treatment intervention in both clinical and
research setting.
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