Abstract #4257
Cerebral Hemodynamics after Reduction of Blood Pressure in Hypertension Measured with 3D pCASL
Xin Lou 1 , Ning Ma 2 , Yanhua Li 3 , Diandian Huang 1 , Ting Wang 1 , Zhenyu Zhou 4 , Bing Wu 4 , and Lin Ma 1
1
Department of Radiology, Chinese PLA General
Hospital, Beijing, China,
2
Department
of Interventional Neuroradiology, Beijing Tiantan
Hospital, Beijing, China,
3
Department
of Cardiology, Chinese PLA General Hospital, Beijing,
China,
4
MR
Research Center, GE Healthcare, Beijing, China
The treatment of hypertension with acute ischemic stroke
is controversial due to decrease mean arterial pressure
may reduce cerebral blood flow to already ischemic
regions and result in further ischemic injury after
intake of antihypertensive drugs. Our findings suggested
that there is a rapid adaptation of the cerebral
hemisphere and brain stem to antihypertensive therapy in
order to protect those areas of the brain from
hypoperfusion; however, an acute reduction in BP may
compromise cerebellar perfusion at the initial stage of
antihypertensive therapy in patients with hypertension.
3D pCASL can be used for monitoring cerebral blood flow
during antihypertensive therapy.
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