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Abstract #4257

Cerebral Hemodynamics after Reduction of Blood Pressure in Hypertension Measured with 3D pCASL

Xin Lou 1 , Ning Ma 2 , Yanhua Li 3 , Diandian Huang 1 , Ting Wang 1 , Zhenyu Zhou 4 , Bing Wu 4 , and Lin Ma 1

1 Department of Radiology, Chinese PLA General Hospital, Beijing, China, 2 Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Beijing, China, 3 Department of Cardiology, Chinese PLA General Hospital, Beijing, China, 4 MR Research Center, GE Healthcare, Beijing, China

The treatment of hypertension with acute ischemic stroke is controversial due to decrease mean arterial pressure may reduce cerebral blood flow to already ischemic regions and result in further ischemic injury after intake of antihypertensive drugs. Our findings suggested that there is a rapid adaptation of the cerebral hemisphere and brain stem to antihypertensive therapy in order to protect those areas of the brain from hypoperfusion; however, an acute reduction in BP may compromise cerebellar perfusion at the initial stage of antihypertensive therapy in patients with hypertension. 3D pCASL can be used for monitoring cerebral blood flow during antihypertensive therapy.

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